![]() Pluripotent stem cell-based cell therapy-promise and challenges. Clonal analysis of the differentiation potential of human adipose-derived adult stem cells. Guilak F, Lott KE, Awad HA, Cao Q, Hicok KC, Fermor B, et al. Adipose-derived stem cells: isolation, expansion and differentiation. Progress toward the clinical application of patient-specific pluripotent stem cells. Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. 2019 8(9):1043.Īasen T, Raya A, Barrero MJ, Garreta E, Consiglio A, Gonzalez F, et al. mRNA-driven generation of transgene-free neural stem cells from human urine-derived cells. Kang PJ, Son D, Ko TH, Hong W, Yun W, Jang J, et al. Generation of human induced pluripotent stem cells from urine samples. Zhou T, Benda C, Dunzinger S, Huang Y, Ho JC, Yang J, et al. ![]() Induced pluripotent stem cell (iPSC)-derived lymphocytes for adoptive cell immunotherapy: recent advances and challenges. Transgene-free disease-specific iPSC generation from fibroblasts and peripheral blood mononuclear cells. Derivation of induced pluripotent stem cells from human peripheral blood T lymphocytes. Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. Hanna J, Markoulaki S, Schorderet P, Carey BW, Beard C, Wernig M, et al. Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Reprogramming of human somatic cells to pluripotency with defined factors. Park IH, Zhao R, West JA, Yabuuchi A, Huo H, Ince TA, et al. Generation of pancreatic β cells for treatment of diabetes: advances and challenges. Shahjalal HM, Abdal Dayem A, Lim KM, Jeon TI, Cho SG. Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors. 2016 15(2):234–49.īan H, Nishishita N, Fusaki N, Tabata T, Saeki K, Shikamura M, et al. Non-integrating episomal plasmid-based reprogramming of human amniotic fluid stem cells into induced pluripotent stem cells in chemically defined conditions. Slamecka J, Salimova L, McClellan S, van Kelle M, Kehl D, Laurini J, et al. Induced pluripotent stem cells generated without viral integration. Stadtfeld M, Nagaya M, Utikal J, Weir G, Hochedlinger K. Induced pluripotent stem cell generation using a single lentiviral stem cell cassette. Sommer CA, Stadtfeld M, Murphy GJ, Hochedlinger K, Kotton DN, Mostoslavsky G. Induced pluripotent stem cell lines derived from human somatic cells. Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, et al. Analysis of transcriptional variability in a large human iPSC library reveals genetic and non-genetic determinants of heterogeneity. 2007 131(5):861–72.Ĭarcamoorive I, Hoffman GE, Cundiff P, Beckmann ND, Dsouza SL, Knowles JW, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. ![]() Maturity-onset diabetes of the young type 2 NDD : IPSC-derived oligodendrocyte progenitor cell LGMD2D : We believe that this rapidly moving field promises many more developments that will benefit modern medicine. Aside from its potential use in regenerative cellular therapy for degenerative diseases, iPSC offers a range of new opportunities for the study of genetic human disorders, particularly, rare diseases. The usability of iPSC technology is changing the fields of disease modeling and precision treatment. Although more researches need to be done, studies have increasingly focused on the potential utility of iPSCs. In this paper, we review new insights into patient-specific iPSC and summarize selected “disease-in-a-dish” examples that model the genetic and epigenetic variations of human diseases. Since the first discovery in 2006 of four factors that are essential for maintaining the basic characteristics of ESC, global researches have rapidly improved the techniques for generating iPSCs. Induced pluripotent stem cells (iPSCs) are produced from adult somatic cells through reprogramming, which behave like embryonic stem cells (ESCs) but avoiding the controversial ethical issues from destruction of embryos.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |